Interesting insecticides: 4α-Alkyloxy-2α/β-bromopodophyllotoxin derivatives were readily prepared with excellent stereoselectivity due to intramolecular steric effects (see scheme). The ratio of two stereoisomers, 2α/β-bromo-4-O-tetrahydropyranylpodophyllotoxin, could be well controlled by the reaction temperature.
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Xu et al. (2011) studied this question.
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