Nine patients with severe primary obsessional illness were treated with mianserin hydrochloride (Org GB 94), in a dose increasing to 20 mg three times daily, for 4 weeks. Six patients improved as assessed by a physician's global rating of improvement. The symptoms on a side-effects check list were less marked during treatment than they had been during the pre-treatment drug-free period.
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Väisänen et al. (1977) studied this question.
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