Two years oral use of chlorhexidine in man

Ultramicrochemical methods were used to assay lactic dehydrogenase, (L.D.H.) malic dehydrogenase (M.D.H.) and glucose‐6‐phosphate dehydrogenase (G‐6‐P.D.H.) in biopsy specimens obtained from palatal mucosa and gingiva of young human volunteers. Half the specimens examined came from individuals who had used a chlorhexidine containing mouthrinse for 18 months and the other half from individuals using a placebo mouthrinse. There were no statistically significant differences in enzyme activity between the two groups. It is concluded that the activities of the glycolytic processes investigated, confirm the lack of any chronic inflammatory process in the chlorhexidine exposed tissue.