Models for time to event provide the link between standard pharmacokinetic–dynamic models disease progression, and clinical outcome events. The biological basis for events may be expressed quantitatively in terms of a hazard function. This tutorial explains hazards and how doses can be linked to events predicted from hazard functions. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e43; doi: 10.1038/psp.2013.18 ; advance online publication 15 May 2013
No takes yet. Share an insight, caveat, or question.
A 2013 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: