Why the study?
Does 4-aminopyridine alter cardiac repolarization, PR interval, or heart rate in patients with spinal cord injury?
Does 4-aminopyridine alter cardiac repolarization, PR interval, or heart rate in patients with spinal cord injury?
Oral 4-aminopyridine up to 30 mg/day for 1 month does not significantly alter heart rate or cardiac repolarization intervals in patients with spinal cord injury.
Supports short-term cardiac safety of 4-aminopyridine in spinal cord injury; extends RCT evidence on its electrophysiological tolerability.
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Isoda et al. (2003) studied this question.
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