Design, Synthesis, and Self-Assembly of “Artificial Dinucleotide Duplexes”

The synthesis of the A−U and G−C functionalized systems 1, 2, 3, and 4 has been accomplished using palladium-mediated cross-coupling reactions. These systems undergo self-association in nonpolar solvents such as CDCl 3 as judged from FABMS and NMR spectroscopic analyses.