Why the study?
Does S-7HNa inhibit the infectivity and replication of HSV-1 in Vero cultured cells?
Does S-7HNa inhibit the infectivity and replication of HSV-1 in Vero cultured cells?
S-7HNa demonstrates significant in vitro antiviral activity against HSV-1 with a higher therapeutic index than its correlative ester S-7.
No clinical adoption warranted for HSV-1; leaves open further preclinical development of S-7HNa.
The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HNa) on the infectivity and replication of herpes simplex virus type 1 in Vero cultured cells was studied. S-7HNa, at the highest concentration lacking cytotoxicity (10 mM), produced, at various inocula, a 70% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production. S-7HNa revealed a therapeutic index higher than that of the correlative ester (S-7).
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Muratore et al. (1995) studied this question.
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