The synthesis of seven bi- and tricyclic chorismate analogues 9-15 and their biological evaluation as mutase inhibitors is described. A tandem Cope rearrangement/Diels-Alder cycloaddition strategy was employed to prepare tricyclo[3.3.1.02,7]non-3-enes functionalized with carboxylic and/or phosphonic acid groups.
No takes yet. Share an insight, caveat, or question.
Clarke et al. (1990) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: