On the X Chromosome of Man

Editorials1 June 1962On the X Chromosome of ManVICTOR A. MCKUSICK, M.D., F.A.C.P.VICTOR A. MCKUSICK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral factors have combined to make the X chromosome of man an object of particular research interest recently and currently (1). The leading factor is, undoubtedly, the cytologic advances which have permitted study of the X chromosome in sex anomalies. The origin and functional significance of the Barr body ("sex chromatin") have been questions for investigation. Discovery of an X-linked blood group has provided a valuable addition to the technical armamentarium for mapping the X chromosome. An hypothesis suggested by Mary Lyon, among others, has stimulated much inquiry into certain functional aspects of the X chromosome.How much and what...References1. MCKUSICK VA: On the X chromosome of man. Quart. Rev. Biol. 37: June, 1962. CrossrefMedlineGoogle Scholar2. PORTERSCHULZEMCKUSICK IHJVA: Linkage of glucose-6-phosphate dehydrogenase and colour-blindness. Nature 193: 506, 1962. CrossrefMedlineGoogle Scholar3. RENWICKSCHULZE JHJ: A computer programme for the processing of linkage data from large pedigrees. Proceedings Second International Conference of Human Genetics, Rome, 1961. Google Scholar4. SCHULZE J: Computer analysis of linkage in human pedigrees, in Methodology in Human Genetics, ed. by Burdette, W. J., Holden-Day, Inc., San Francisco, 1962. Google Scholar5. BOYERFERGUSON-SMITHGRUMBACH SHMAMM: The lack of influence of parental age and birth order in the aetiology of nuclear sex chromatin-negative Turner's syndrome. Ann. Human Genet. 25: 215, 1961. CrossrefGoogle Scholar6. CHILDSCANTOLINODYKE BSMK: Observations on sex differences in human biology. Bull. Johns Hopkins Hosp. 110: 134, 1962. MedlineGoogle Scholar7. VANDENBERGMCKUSICKMCKUSICK SGVAAB: Twin data in support of the Lyon hypothesis. Nature 193: 505, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medical Genetics Department of Medicine Johns Hopkins University School of Medicine Baltimore 5, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFVIII GeneticsOf mice and cats (both calico): Mary F Lyon, FRS (1925-2014)Partial expression of sex-linked recessive amelogenesis imperfecta in females compatible with the Lyon hypothesisCOMBINED HAEMOPHILIA AND CHRISTMAS DISEASE: A GENETIC STUDY OF A PATIENT AND HIS RELATIVESHemophilia A in a Phenotypically Normal Female with XX/XO MosaicismGenes, Chromosomes and DentistryTHE SEPARATION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE-DEFICIENT ERYTHROCYTES FROM THE BLOOD OF HETEROZYGOTES FOR GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCYMedical genetics 1962Genetical linkage between the loci for glucose-6-phosphate dehydrogenase deficiency and colour-blindness in American Negroes 1 June 1962Volume 56, Issue 6Page: 991-996KeywordsBlood groupsChromatinX chromosomes Issue Published: 1 June 1962 PDF DownloadLoading ...