It is getting easier and easier to determine complete genome sequences—of model organisms, animals and plants of commercial importance, and humans: Craig Venter, Jim Watson, the 1000 Genome Project, soon you and me. Now that researchers have all this information at hand, the focus has shifted in many cases to manipulating particular sequences to determine their function or to alter their impact. A new study by Jinek et al.1 proposes a new approach—based on the oldest of DNA recognition principles—to the design of reagents that can target specific genomic sequences.
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Dana Carroll (2012) studied this question.
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