Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

The recent years have witnessed a rise in the number of intrinsically disor-dered proteins (IDPs), also known as hybrid proteins, which possess both struc-tured domains and biologically important intrinsically disordered protein regions (IDPRs). These proteins challenge the “one sequence—one structure—one func-tion ” concept by demonstrating that the lack of stable tertiary and/or secondary structure does not preclude proteins from being biologically active (Wright