The cysteine-derived thiol group of coenzyme A (CoA) is the key functional group involved in catalysis by this cofactor. Since CoA analogues are potent antibiotics, it is critical that CoA biosynthetic enzymes show high selectivity for the incorporation of cysteine over closely related amino acids such as serine (see scheme). In this study, we determine that the cysteine/serine selectivity ratio in CoA biosynthesis is >5.0×105, and localize this selectivity to two enzymes in the pathway.
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Strauss et al. (2004) studied this question.
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