Why the study?
Although the liver plays a protective role in myocardial infarction, very little is known about the underlying mechanisms.
Population
Preclinical model of myocardial infarction
Design
Preclinical
Authors
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Supports hepatic MR/FGF21 as post-MI protective axis; hypothesis-generating, should not yet change practice.
This study identifies an IL-6/STAT3/MR/FGF21 signaling axis that mediates heart-liver cross-talk during myocardial infarction, revealing potential new therapeutic targets for MI and heart failure.
Du et al. (2023) studied this question.
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