What question did this study set out to answer?

To characterize penicillin-binding proteins in three Proteus species and compare their biochemical properties to those of Escherichia coli K-12.

January 1, 1979Journal of BacteriologyOpen Access

Penicillin-binding proteins in Proteus species

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Authors

SOSatoshi OhyaNihon University MYM YamazakiTokyo Institute of Technology SSS. SugawaraSendai Kousei Hospital

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Implication

Comparative biochemical study reveals conserved penicillin-binding protein profiles across three Proteus species, indicating strong structural homology with Escherichia coli targets.

Key Points

To characterize penicillin-binding proteins in three Proteus species and compare their biochemical properties to those of Escherichia coli K-12.
Analyzed penicillin-binding proteins from Proteus mirabilis, Proteus morganii, and Proteus rettgeri using sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis.
Compared profiles against Escherichia coli K-12 across electrophoretic mobilities, beta-lactam binding affinities, induced morphological alterations, beta-lactamase localization, and thermostability.
Penicillin-binding protein profiles, electrophoretic mobilities, and biochemical characteristics were consistent across all three examined Proteus species.
Proteus penicillin-binding proteins correlated closely with corresponding proteins in Escherichia coli K-12, displaying only slight variations in migration and antibiotic binding patterns.

Cite This Study

Ohya et al. (1979) studied this question.

synapsesocial.com/papers/6a922f023eb7c78f2e41da05 https://doi.org/10.1128/jb.137.1.474-479.1979

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Implication

Comparative biochemical study reveals conserved penicillin-binding protein profiles across three Proteus species, indicating strong structural homology with Escherichia coli targets.

Penicillin-binding proteins in Proteus species

Discussion

Member takes

Implication

Key Points

Cite This Study

Penicillin-binding proteins in Proteus species

Discussion

Member takes

Implication

Key Points

Cite This Study

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