Highlights a rare but severe complication of massive thromboembolism associated with prothrombin complex concentrate use during complex cardiac surgery.
May warrant caution with prothrombin complex concentrate post-bypass; hypothesis-generating case report leaves risk quantification open.
Prothrombin complex concentrates are increasingly used during complex cardiac surgery with cardiopulmonary bypass. Reports describing massive thromboembolism after administration of prothrombin complex concentrates are rare. We report a case of a patient developing massive intracardiac and pulmonary artery thrombus formations during infusion of a moderate dose of prothrombin complex concentrate after separation from cardiopulmonary bypass for complex open heart surgery.
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Koster et al. (2014) studied this question.
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