Cimetidine and Effect of Warfarin

Letters and Correction1 June 1979Cimetidine and Effect of WarfarinBRUCE A. WALLIN, M.D., ART JACKNOWITZ, PHARM, D., PETER C. RAICH, M.D.BRUCE A. WALLIN, M.D.Search for more papers by this author, ART JACKNOWITZ, PHARM, D.Search for more papers by this author, PETER C. RAICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-993_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report of Silver and Bell in the March issue (1) describes a patient in whom Cimetidine appeared to potentiate the hypoprothrombinemic effect of warfarin. We report an additional case of this potentially harmful drug interaction.A 46-year-old white man had coronary artery revascularization in January 1975. He was placed on warfarin sodium (Coumadin®) at a dosage of 7 mg daily. On this dose, his prothrombin time remained stable within 1.7 to 1.9 times control. In September 1978, because of obstruction of both bypass grafts, repeat coronary revascularization was done. He was discharged on Coumadin, 6 mg...References1. SILVER B and BELL W: Cimetidine potentiation of the hypoprothrombinemic effect of warfarin. Ann Intern Med 90:348-349, 1979 LinkGoogle Scholar2. FLIND A: Cimetidine and oral anticoagulants (letter). Br Med J 2:1367, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE A. WALLIN, M.D.; ART JACKNOWITZ, PHARM, D.; PETER C. RAICH, M.D.Affiliations: West Virginia University Morgantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Histamine H2-Receptor Antagonists on Acute Inflammatory of the Rat Paw OedemaSuboptimal Prescribing in Elderly Outpatients: Potentially Harmful Drug-Drug and Drug-Disease CombinationsDrug Interactions with Agents Used to Treat Gastrointestinal DiseaseDrug Interactions with Agents Used in the Treatment of Cardiovascular DiseaseEffects of Diltiazem and Cimetidine on Theophylline Oxidative MetabolismDo All Histamine 2 -Antagonists Cause a Warfarin Drug Interaction?Haematological Adverse Effects of Histamine H2-Receptor AntagonistsLack of interaction of ranitidine with amitriptylineFemoxetine and cimetidine: Interaction in healthy volunteersCimetidine versus famotidine: the effect on the pharmacokinetics of theophylline in ratsCimetidine interaction with amitriptylineSicherheitsprofil des H2-Blockers RaniditinCimetidine-drug interactionsTrauma and oral anticoagulantsEinflu� von Histamin H2-Rezeptorantagonisten auf die hepatische Elimination von ArzneimittelnEffect of Cimetidine on Phenytoin Serum LevelsReview of Cimetidine Drug InteractionsCimetidine as an Inhibitor of Drug Metabolism: Therapeutic Implications and Review of the LiteratureInteraktionen von UlcustherapeuticaCimetidineCimetidine Impairs Elimination of Chlordiazepoxide (Librium) in ManPAUL V. DESMOND, M.B., B.S., RASHMI V. PATWARDHAN, M.D., STEVEN SCHENKER, M.D., K. V. SPEEG Jr., M.D., Ph.D.Effect of Cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeinBEHAVIOURAL REACTIONS TO TRIAZOLAMCIMETIDINE INTERACTION WITH WARFARIN 1 June 1979Volume 90, Issue 6Page: 993-993KeywordsCoronary arteriesCoronary revascularizationDrug interactionsProthrombin timeRevascularizationSodium ePublished: 1 December 2008 Issue Published: 1 June 1979 PDF downloadLoading ...