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Bioinformatic analysis reveals that sulfur metabolism drives tumor progression in liver hepatocellular carcinoma via the PPAR pathway, highlighting novel metabolic targets.
More and more studies have shown that sulfur metabolism plays an important role in various cancers, but not much research has been done on Liver Hepatocellular Carcinoma (LIHC). This study aimed to discovered genes with high correlation between sulfur metabolism and LIHC. GSE148985, a dataset containing 10 experimental samples and 5 control samples was used to find differentially expressed genes (DEGs) in sulfur metabolism; and DEGs in LIHC were found from The Cancer Genome Atlas(TCGA)database. Subsequently, 11 DEGs were obtained, through various bioinformatics methods and further analysis to obtain the target genes, our results showed that the sulfur metabolism promotes the progression of LIHC. As a result, we illustrate that the sulfur metabolism promotes the progression of LIHC via the PPAR signaling pathway.
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Wei et al. (2024) studied this question.
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