A series of coumarin tetrahydro‐ β ‐carboline hybrids 3 have been synthesized by the Pictet‐Spengler reaction. Stoichiometrically controlled DDQ oxidation has led to dihydro 4 and β ‐carboline 5 . In vitro anticancer activity against 60 cell lines has revealed the potency of 3 f , 4 a and 5 c . In silico studies indicate the binding properties of 5 c with Kinesin spindle protein (KSP) and tubulin protein. Gel electrophoresis studies revealed that compound 3 f partially cleaved the CT‐DNA, whereas the ring C aromatized compound 5 c completely cleaved the CT‐DNA. Structures of the newly synthesized compounds are confirmed by spectroscopic and X‐ray studies.
No takes yet. Share an insight, caveat, or question.
Samundeeswari et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: