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Hydrogen peroxide (H2O2) is an important reactive oxygen species (ROS) that plays a significant role in many biological systems. A new water‐soluble polymeric probe appended with pyrene and boronic acid groups was designed and synthesized for the detection of H2O2. Glycidyl methacrylate (GMA) and N,N‐dimethylacrylamide (DMA) were copolymerized by reversible addition‐fragmentation chain‐transfer (RAFT) polymerization to yield poly(glycidyl methacrylate‐co‐dimethylacrylamide) [p(GMA‐co‐DMA)](P1). The subsequent ring‐opening reaction between the secondary amine of (3‐((pyren‐1‐ylmethyl)amino)phenyl)boronic acid with the epoxide unit of P1 yielded a target polymer, P2. In the presence of H2O2, the phenyl boronic acid group of P2 transformed to a phenol group, which was accompanied by turn‐off fluorescence. P2 also exhibited pH‐tunable detection sensitivity. This polymeric probe is anticipated to promote the development of stimuli‐responsive water‐soluble polymers with fluorescence‐sensing behaviors.
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Annisa et al. (2020) studied this question.
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