A simple procedure is proposed for increasing the size of NOEs in NMR studies of small molecules. The method involves the use of a mixed solvent (Me2SO‐d6‐D2O) to increase the viscosity of the solution such that ωtc >1. The advantages of this solvent system and approach are compared with other approaches currently in use.
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Fesik et al. (1987) studied this question.
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