The Occurrence of Intracellular Iron in Gaucher's Disease

Article1 August 1960THE OCCURRENCE OF INTRACELLULAR IRON IN GAUCHER'S DISEASEMORTIMER LORBER, M.D.MORTIMER LORBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-2-293 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGaucher's disease is a metabolic disorder characterized by the presence in various organs of large cells containing the cerebroside, kerasin.1, 2These cells are found in greatest number in the bone marrow, spleen, liver and lymph nodes,3structures which also contain the bulk of the reticuloendothelial cells of the body. The latter are believed to be the progenitors of Gaucher cells,4, 6in addition to their other functions, which include a role in the metabolism and storage of iron.7-12Earlier papers have disagreed as to the distribution of tissue iron in this disorder; it has therefore been deemed worth while...Bibliography1. Lieb H: Cerebrosidspeicherung bei Splenomegaly, Typus Gaucher, Ztschr. f. physiol. Chem. 140: 305, 1924. CrossrefGoogle Scholar2. Epstein E: Beitrag zur Chemie der Gaucherschen Krankheit, Biochem. Ztschr. 145: 398, 1924. Google Scholar3. BrillMandelbaumLibman NEFSE: A case of "splenomegalie primitif" with involvement of the hemopoietic organs, Proc. New York Path. Soc. 4: 243, 1904. Google Scholar4. Schlagenhaufer F: Über meist familiar vorkommende histologisch charakteristische splenomegalien (Typus Gaucher), Virchows Arch. f. path. Anat. 87: 125, 1907. CrossrefGoogle Scholar5. MandelbaumDowney FSH: Histopathology and biology of Gaucher's disease, Folia haemat. 20: 139, 1915. 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C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron storage in liver, bone marrow and splenic Gaucheroma reflects residual disease in type 1 Gaucher disease patients on treatmentHyperferritinemia and iron metabolism in Gaucher disease: Potential pathophysiological implicationsLiver Fibrosis in Type I Gaucher Disease: Magnetic Resonance Imaging, Transient Elastography and Parameters of Iron StorageTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examplesGaucherʼs disease type I: a disease masked by the presence of abnormal laboratory tests common to primary liver diseaseNichtentzündliche Erkrankungen des UnterhautbindegewebesMorbus GaucherIron Distribution in Adult-Type Gaucher's DiseaseGaucher's diseaseHistochemische und biochemische Untersuchungen bei Morbus GaucherElectron microscopy of Gaucher cellsCerebral Lipidosis of Unclear Nature 1 August 1960Volume 53, Issue 2Page: 293-305KeywordsCellsFerritinHemolytic anemiaHospital medicineMetabolic disordersPhosphatasesPotassiumResearch fundingSpleenTissue distribution ePublished: 1 December 2008 Issue Published: 1 August 1960 PDF downloadLoading ...