T-cell Response Induced by the BNT162b2 COVID-19 Vaccine in Children

Isabel Vogler; Stephanie Renken; Rolf Hilker; Bonny Gaby Lui; Andrew Finlayson; Alejandra Gurtman; Charu Sabharwal; Nicholas Kitchin; Stephen Lockhart; William C. Gruber; Kathrin U. Jansen; Kena A. Swanson; Özlem Türeci; Uğur Şahin

doi:10.1093/ofid/ofaf699

November 19, 2025Open Forum Infectious DiseasesOpen Access

T-cell Response Induced by the BNT162b2 COVID-19 Vaccine in Children

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Key Points

To evaluate the humoral and cellular immune responses, specifically neutralizing antibodies and T-cell immunogenicity, induced by the BNT162b2 vaccine in children.
Evaluated participants aged 10-11 years within Phase 1 and Phase 2/3 clinical trials (NCT04816643).
Administered an initial primary regimen of two 10 µg doses of BNT162b2 spaced 21 days apart, followed by a third 10 µg dose at 6 months.
Assessed post-vaccination immune outcomes, including neutralizing antibody production and antigen-specific T-cell activity.
Vaccination with BNT162b2 elicited detectable neutralizing antibody responses in participants aged 10-11 years.
Administration of the vaccine regimen successfully induced antigen-specific T-cell immunogenicity.

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Implication

Demonstrates T-cell and neutralizing antibody responses in children receiving BNT162b2, indicating cellular and humoral protection against COVID-19.

Abstract

Phase 1 and Phase 2/3 trials (NCT04816643) demonstrated that the mRNA-based coronavirus disease 2019 (COVID-19) vaccine BNT162b2 is tolerable and efficacious in (5-11-year-olds) following two 10 µg doses 21 days apart, and a third 10 µg dose after 6 months. Here, we show that vaccination induces neutralizing antibodies and T-cell immunogenicity in 10-11-year-old participants.

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Vogler et al. (2025) studied this question.

synapsesocial.com/papers/6a9242b4ce96c166766c4c35 https://doi.org/10.1093/ofid/ofaf699

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T-cell Response Induced by the BNT162b2 COVID-19 Vaccine in Children

Key Points

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Implication

Abstract

Discussion

Cite This Study

T-cell Response Induced by the BNT162b2 COVID-19 Vaccine in Children

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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