August 1, 1989Pacing and Clinical Electrophysiology
Pharmacological Characterization of Conduction Over a Mahaim Fiber: Evidence for Adenosine Sensitive Conduction
Why the study?
How does conduction over a Mahaim fiber respond to various pharmacological agents, specifically adenosine?
Population
1 patient with a Mahaim fiber (nodoventricular pathway)
Design
Case_report
Authors
Discussion
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Implication
Hypothesis-generating for Mahaim fiber pharmacology; leaves open consistency across patients and should not yet change practice.
Structured PICO
How does conduction over a Mahaim fiber respond to various pharmacological agents, specifically adenosine?
P
Population
1 patient with a Mahaim fiber (nodoventricular pathway)
I
Intervention
Administration of adenosine, procainamide, encainide, verapamil, edrophonium, phenylephrine, and isoproterenol
O
Outcome
Response to conduction over the Mahaim pathwaysurrogate
Mahaim fibers are decrementally conducting pathways that are adenosine sensitive, suggesting conduction is not mediated by calcium channels.
Cite This Study
Ellenbogen et al. (1989) studied this question.