Observational study reveals maternal serum to amniotic fluid anti-D ratios increase with gestational age in sensitized pregnancies, indicating no predictive value for disease severity.
Eighty-seven pairs of samples of maternal serum and amniotic fluid were analysed for anti-D levels at varying stages of gestation. There was a marked positive correlation between the maternal serum level and that in the amniotic fluid. The ratio of maternal serum anti-D to liquor anti-D was calculated for 61 pairs of data and was found to increase as gestation advanced. However, it was neither of clinical value in predicting the severity of haemolytic disease of the newborn nor the Rh(D) group of the fetus.
No takes yet. Share an insight, caveat, or question.
NEIL et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: