March 23, 2012BMC Musculoskeletal DisordersOpen Access

Calpain 3 is important for muscle regeneration: Evidence from patients with limb girdle muscular dystrophies

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Population

32 patients with muscular dystrophy: 22 with LGMD2A, 5 with LGMD2I, and 5 with Becker muscular dystrophy.

Design

Cross-sectional

Authors

SHSimon HauerslevUniversity of Copenhagen MSMarie-Louise SveenUniversity of Copenhagen MDMorten DunøCopenhagen University Hospital

Discussion

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Implication

Hypothesis-generating for calpain-3-specific regeneration defects in LGMD2A; prospective studies needed before clinical or therapeutic implications.

Structured PICO

Population

32 patients with muscular dystrophy: 22 with LGMD2A (calpain 3 deficiency), 5 with LGMD2I (secondary reduction in calpain 3), and 5 with Becker muscular dystrophy (BMD, normal calpain 3 levels).

Comparator

Patients with LGMD2I and BMD (normal or secondary reduction in calpain 3)

Outcome

Muscle regeneration assessed by developmental markers (neonatal myosin heavy chain, vimentin, MyoD, myogenin) and internally nucleated fiberssurrogate

Complete lack of functional calpain 3 in LGMD2A leads to diminished muscle regeneration and aberrant regeneration signs compared to other muscular dystrophies.

Cite This Study

Hauerslev et al. (2012) studied this question.

synapsesocial.com/papers/6a924eaa78040453609636f0 https://doi.org/10.1186/1471-2474-13-43

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Implication

Hypothesis-generating for calpain-3-specific regeneration defects in LGMD2A; prospective studies needed before clinical or therapeutic implications.

Calpain 3 is important for muscle regeneration: Evidence from patients with limb girdle muscular dystrophies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calpain 3 is important for muscle regeneration: Evidence from patients with limb girdle muscular dystrophies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider