The conjugate additions of the organocopper(I) reagents 22 and 27 to the enantiomerically homogeneous bicyclic enone 4 provided, after epimerization (NaOMe, MeOH) of the resultant product mixtures and appropriate chromatographic separations, the bicyclo[4.3.0]nonan-2-ones 24 and 28 . Compounds 24 and 28 were readily converted, via two synthetic steps in each case, into the sesquiterpenoids (−)-homalomenols B ( 2 ) and A ( 1 ), respectively.
No takes yet. Share an insight, caveat, or question.
Piers et al. (1996) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: