What question did this study set out to answer?

Determine the genetic factors controlling lymphocyte production of interferon gamma and evaluate their linkage to loci regulating tumor infiltration and tumor susceptibility.

August 4, 2009Cancer Immunology ImmunotherapyOpen Access

Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

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Authors

MLMarie LipoldováCharles University HHHelena HavelkováInstitute of Molecular Genetics JBJana BadalováCzech Academy of Sciences

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Implication

Murine linkage study uncovers co-localization of interferon-gamma loci with tumor infiltration genes in mice, suggesting inherited immune variations govern tumor control.

Key Points

Determine the genetic factors controlling lymphocyte production of interferon gamma and evaluate their linkage to loci regulating tumor infiltration and tumor susceptibility.
Stimulated lymphocytes from O20/A and OcB-9/Dem mouse strains in vitro with irradiated allogeneic splenocytes (C57BL/10SnPh or BALB/cHeA) or concanavalin A to quantify interferon gamma production.
Genotyped (O20 x OcB-9) F2 intercross mice with microsatellite markers following allogeneic mixed lymphocyte culture stimulation to map cytokine-controlling loci.
Lymphocytes from O20/A mice produced lower levels of interferon gamma compared to OcB-9/Dem mice across all stimulation assays.
Linkage analysis in F2 mice identified four interferon gamma-regulating loci (Cypr4–Cypr7).
Each identified Cypr locus mapped in close genetic proximity to one of four known lymphocyte infiltration loci (Lynf1–Lynf4) and tumor susceptibility clusters.

Cite This Study

Lipoldová et al. (2009) studied this question.

synapsesocial.com/papers/6a925245ad37002f23384a22 https://doi.org/10.1007/s00262-009-0739-y

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Implication

Murine linkage study uncovers co-localization of interferon-gamma loci with tumor infiltration genes in mice, suggesting inherited immune variations govern tumor control.

Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

Discussion

Member takes

Implication

Key Points

Cite This Study

Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

Discussion

Member takes

Implication

Key Points

Cite This Study

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