Early Reproductive Loss

Although at least 15% of clinically recognized pregnancies end in spontaneous abortion, a much higher loss varying from 8-78% probably occurs subclinically during very early gestation. This 'early reproductive loss' is largely presumptive and may be caused by factors such as chromosomal abnormalities, infections, endocrine deficiencies, uterine disease, and immunological factors. Little may be offered by way of treatment; but more recently, immunotherapy appears an attractive possibility in selected cases.