1967; Allfrey & Mirsky, 1952), where its highest activity is usually observed in actively dividing cells The literature contains various conflicting reports on the localization of acid deoxyribonuclease. Webb (1953) described deoxyribonuclease II as a cytoplasmic enzyme, Brown, Jacobs & Laskowski (1952) reported its presence in the nucleus, Schneider & Hogeboom (1952) and Sinsheimer (1957) found it in the mitochondria, and Bowers (1964) and de Duve, Wattiaux & Baudhuin (1962) described it as a lysosomal enzyme, and discounted the presence of acid deoxyribonuclease in nuclei and mitochondria on the grounds that the deoxyribonuclease activity in them was caused by contamination with lysosomes, and therefore that acid deoxyribonuclease is located only in the lysosomes.
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Slor et al. (1971) studied this question.