A C2-protected imidazolium salt that generates an abnormal N-heterocyclic carbene (NHC) was applied for the palladium-catalyzed Suzuki−Miyaura coupling reactions. The abnormal NHC precursor promoted the reactions while suppressing homocoupling of aryl boronic acid, which was observed with the corresponding normal NHC precursor. The related well-defined abnormal NHC-based palladium complexes also showed better activity than the normal NHC-based analogues, exhibiting faster reaction rates especially at the initial stage of the reaction.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: