Why the study?
Does chronic administration of bufalin increase blood pressure in normal and reduced renal mass rats?
Population
Normal rats and 70% reduced renal mass rats on a salt-free diet
Comparison
Bufalin intraperitoneally for 6 weeks vs Vehicle or equimolar dose of ouabain
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Bufalin raises BP in normal and reduced-renal-mass rats; hypothesis-generating for pressor effects in human hypertension.
Does chronic administration of bufalin increase blood pressure in normal and reduced renal mass rats?
Chronic administration of bufalin, a sodium-potassium ATPase inhibitor, acts as a pressor agent in rats, particularly in the setting of reduced renal mass.
Pamnani et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: