Trifluoroacetylated peptides are much more potent inhibitors of human leukocyte elastase than the corresponding unblocked, acylated or benzyloxycarbonylated peptides. The most active compound was trifluoroacetyl-Val-Tyr-Val (Ki = 1.3 micron). A number of free and NH2-terminal-substituted peptides exhibited similar affinities for porcine pancreatic and human leukocyte elastase, indicating that these two enzymes must have similar specificity sites.
No takes yet. Share an insight, caveat, or question.
Lestienne et al. (1977) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: