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Summary. An in vitro coagulation defect, shown by a prolongation of the thrombin time and a discrepancy between fibrinogen determinations with different methods, is described in a young healthy female. The disturbance in the fibrinogen‐fibrin conversion, using different enzymes, persisted after purification of fibrinogen from plasma and was shown to be caused by a delayed aggregation of the patient's fibrin monomers. The presence of a delayed fibrinogen‐fibrin conversion in several members of the family indicates an inherited variant.
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Verhaeghe et al. (1974) studied this question.
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