A water-soluble expolysaccharide (EPS) was prepared from Bifidobacterium animalis RH by enzymatic hydrolysis, ethanol precipitation and Sepharose CL-6B column chromatography. Its immunomodulating activity was evaluated using murine macrophage cell line RAW 264.7. The data obtained showed that the EPS promoted proliferation and phagocytosis activity of RAW 264.7 cells. In addition, the EPS promoted RAW 264.7 cells to produce NO, IL-6, TNF-α, MCP-1 and MIP-1α in a dose-dependent manner. Further work revealed that the EPS activated RAW 264.7 cells majorly through TLR4.
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Liu et al. (2016) studied this question.
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