Why the study?
Does etomidate alter changes in circulating metabolites associated with pelvic surgery in healthy female patients?
Does etomidate alter changes in circulating metabolites associated with pelvic surgery in healthy female patients?
Cortisol suppression by etomidate during pelvic surgery does not significantly alter circulating metabolites, suggesting cortisol plays only a minor role in the metabolic response to surgery.
Etomidate cortisol suppression suggests minor role for cortisol in surgical metabolism; hypothesis-generating and should not change practice.
The effects of cortisol suppression by etomidate on the changes in circulating metabolites associated with pelvic surgery were investigated in healthy female patients. The use of etomidate resulted in the inhibition of cortisol secretion for 24 h compared with a control group of patients. However, the inhibition of steroidogenesis was not associated with a significant effect on blood glucose, blood lactate and plasma nonesterified fatty acid values, although the glycaemic response to surgery was consistently less in those patients who received etomidate. Heart rate and arterial pressure were significantly decreased during surgery in the etomidate group compared with the control group, but were similar in the postoperative period when the difference in plasma cortisol between the groups was greatest. The results suggest that cortisol has only a minor role in determining changes in circulating metabolites associated with surgery.
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Lacoumenta et al. (1986) studied this question.
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