What question did this study set out to answer?

To examine the physiological and electrophysiological effects of quinidin sulphate on normal, spontaneously beating canine and guinea-pig hearts in vivo.

January 1, 1923Archives of Internal Medicine

An Experimental and Clinical Study of Quinidin Sulphate: I. Experimental

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Why the study?

What are the electrocardiographic effects of quinidin sulphate on normal dog and guinea-pig hearts?

Population

Normal dogs and guinea-pigs (spontaneously beating heart, intact thorax)

Design

Preclinical

Authors

HKHorace Marshall KornsUniversity of Iowa

Discussion

Member takes

Implication

No clinical guidance from this animal model; leaves open human validation of quinidine ECG effects.

Key Points

To examine the physiological and electrophysiological effects of quinidin sulphate on normal, spontaneously beating canine and guinea-pig hearts in vivo.
Canine subjects were fully anesthetized using ether or chlorbutanol with morphine.
Lead II electrocardiograms were continuously recorded via limb electrodes attached to a string galvanometer with the thorax kept closed.
Vagus nerves were isolated in the neck, sectioned, and stimulated electrically at the peripheral end using an inductorium coil.
Lead II electrocardiographic monitoring successfully captured spontaneous cardiac electrical conduction and rhythm dynamics in intact animal models.
Peripheral vagal stimulation during closed-chest observation established a baseline for evaluating autonomic nerve modulation under quinidin exposure.

Structured PICO

What are the electrocardiographic effects of quinidin sulphate on normal dog and guinea-pig hearts?

Population

Normal dogs and guinea-pigs (spontaneously beating heart, intact thorax)

Intervention

Quinidin sulphate

Outcome

Electrocardiographic changes (Lead II)surrogate

This experimental study describes a methodology for evaluating the electrocardiographic effects of quinidine on normal animal hearts.

Cite This Study

Horace Marshall Korns (1923) studied this question.

synapsesocial.com/papers/6a92689543dadb0f15437278 https://doi.org/10.1001/archinte.1923.00110130018003

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An Experimental and Clinical Study of Quinidin Sulphate: I. Experimental

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

An Experimental and Clinical Study of Quinidin Sulphate: I. Experimental

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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