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November 29, 2022Open Access

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk

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Why the study?

miRNA-dependent mechanisms regulating inflammation and calcification, or miRNA-mediated cell-cell crosstalk during the pathogenesis of aortic valve stenosis, remain poorly understood.

Population

Aortic valve tissue explants from AVS patients, murine AVS models, and valvular cells

Comparison

AVS valve tissue vs non-calcified valvular tissue explants

Design

Translational study with human tissue arrays, murine models, and in vitro experiments

Authors

PGPR. GoodyDCD ChristmannDGDeborah Goody

Discussion

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Overview

May represent an AVS therapeutic target; animal data leaves open human translation.

Structured PICO

P
Population
Human aortic valve tissue explants from AVS patients and non-calcified valvular tissue explants from patients undergoing SAVR; murine AVS model; in vitro valvular interstitial cells.
I
Intervention
Extracellular vesicle-associated miR-145-5p (mechanistic evaluation)
C
Comparator
Non-calcified valvular tissue explants
O
Outcome
Expression levels of miR-145-5p and its effect on calcification via the ZEB2-ALPL axissurrogate

Elevated levels of EV-associated miR-145-5p contribute to aortic valve stenosis progression by promoting calcification through the ZEB2-ALPL axis, identifying a potential therapeutic target.

Cite This Study

Goody et al. (2022) studied this question.

synapsesocial.com/papers/6a9269eb3da4caa5ce964597https://doi.org/10.1101/2022.11.29.518326
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk2025
  2. 2Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk2025 · 5 citations
  3. 3Altered MicroRNA Expression Is Responsible for the Pro‐Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves2017 · 45 citations
  4. 4miR‐138‐5p Inhibits Aortic Valve Interstitial by Targeting SLC39A14 and Activating Nrf2 Signaling2026
  5. 5Exploring the regulation of circulating factors involved in aortic valve sclerosis onset2024