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Histamine was detected and quantitatively determined from “Samma-Sakuraboshi” (dried mackerel-pike), which caused food poisoning. The amount of histamine detected did not agree with the result of lethal dose test in animals. Chromatographic fractionation through alumina failed to show the presence of any toxic substance other than histamine (cf. Table III), but the presence was confirmed of a factor that cooperates with histamine.
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Miyaki et al. (1954) studied this question.
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