Fundectomy-Evoked Osteopenia in Pigs Is Mediated by the Gastric-Hypothalamic-Pituitary Axis

Marcin R. Tatara; Witold Krupski; Ewa Śliwa; Ryszard Maciejewski; A Dąbrowski

doi:10.3181/0608-rm-196

December 1, 2007Experimental Biology and Medicine

Fundectomy-Evoked Osteopenia in Pigs Is Mediated by the Gastric-Hypothalamic-Pituitary Axis

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Key Points

To evaluate the impact of gastric fundectomy on skeletal properties in pigs and test whether resulting osteopenia is mediated by dysfunction in the gastric-hypothalamic-pituitary axis.
Assigned 40-day-old male piglets to either experimental fundectomy (n = 6) or pair-fed sham surgery (n = 6) and maintained them until 8 months of age.
Assessed bone mineral density, bone mineral content, and mechanical and geometric properties of lumbar vertebrae (L1–L6) and the right humerus using DEXA, QCT, compression, and three-point bending tests.
Measured serum concentrations of ghrelin, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and selected mineral elements.
Fundectomy reduced pig body weight by 66% (P < 0.0001) and caused significant reductions in bone weight, bone mineral density, bone mineral content, and mechanical parameters of both lumbar vertebrae and humerus (P < 0.01).
Serum concentrations of ghrelin, GH, and IGF-1 decreased by 74.4%, 90.6%, and 54.6%, respectively, in fundectomized animals compared to sham controls (all P < 0.001).
Fundectomized pigs showed significant mineral reductions in serum calcium (-15.5%), magnesium (-45.3%), iron (-26.7%), and copper (-26.2%).

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Implication

Controlled trial demonstrates fundectomy-induced osteopenia and neuroendocrine suppression in piglets, indicating a key gastric-hypothalamic-pituitary role in bone health.

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Tatara et al. (2007) studied this question.

synapsesocial.com/papers/6a926e589da65ccb7849f493 https://doi.org/10.3181/0608-rm-196

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Fundectomy-Evoked Osteopenia in Pigs Is Mediated by the Gastric-Hypothalamic-Pituitary Axis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Fundectomy-Evoked Osteopenia in Pigs Is Mediated by the Gastric-Hypothalamic-Pituitary Axis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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