Answers are grounded in this paper and cite their sources.
An improved synthesis for the nonionic detergent n-octyl-beta-D-glucoside (detergent 2) is described. The key modification over earlier methods is the utilization of n-octyl alcohol as the limiting reagent in the condensation between bromide 1 and n-octyl alcohol. A 60-70% overall yield of 2 is obtained without isolation of the intermediate. The beta-configuration at the anomeric carbon atom of 2 was confirmed by 100 mHz NMR spectroscopy.
No takes yet. Share an insight, caveat, or question.
Keana et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: