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June 26, 2024Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

The discussed study challenges the idea that thrombosis is responsible for rapid lethality from high-dose intravenous polyP and reports that histidine-rich glycoprotein (HRG) protects against polyP-induced death.

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Population

Mice (discussed in the context of Malik et al.'s study on polyphosphate and histidine-rich glycoprotein)

Design

Editorial

Authors

JMJames H. Morrissey

Discussion

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Overview

Platelet polyP promotes thrombosis in mice; leaves open its relevance as a human therapeutic target.

Structured PICO

P
Population
Mice (discussed in the context of Malik et al.'s study on polyphosphate and histidine-rich glycoprotein)
I
Intervention
High-dose intravenous polyphosphate (polyP)
O
Outcome
PolyP-induced death and thrombosis

The editorial discusses new evidence challenging the role of thrombosis in polyP-induced rapid lethality and highlighting the protective role of histidine-rich glycoprotein.

Cite This Study

James H. Morrissey (2024) studied this question.

synapsesocial.com/papers/6a92751ffa60aefc093aa6ebhttps://doi.org/10.1161/atvbaha.124.321178
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