Effects of Platelet‐Rich Plasma on Sinus Bone Graft: Meta‐Analysis

BACKGROUND: This meta-analysis investigates the effects of platelet-rich plasma (PRP) on the sinus bone graft. METHODS: PubMed, the Cochrane Library, and EMBASE were searched in January 2010. RESULTS: Of 61 articles searched, eight controlled clinical trials, which included a total of 352 sinus bone graft cases in 191 patients, were included in the final analysis. In the fixed-effects meta-analysis, the implant survival was not significantly different between two groups in the patient-based data of four studies (relative risk [RR]: 1.02; 95% confidence interval [CI]: 0.97 to 1.08) and in the implant-based data of three studies (RR: 1.02; 95% CI: 0.99 to 1.04). The bone formation was significantly greater in the intervention group in the random-effects model (standardized mean difference [SMD]: 1.30; 95% CI: 0.21 to 2.39) in five studies with significant heterogeneity (I(2) = 76.2%). The bone-to-implant contact was not significantly different between two groups in the random-effects model (SMD: 1.02; 95% CI: -1.65 to 3.70) in two studies with significant heterogeneity (I(2) = 82.4%). CONCLUSION: The present study indicates that there was sufficient evidence to support the use of PRP for bone formation on a sinus bone graft, whereas there was no significant effect on the implant survival and bone-to-implant contact.