Synthesis of 3‐(2‐Aminoethyl)pyrrole Derivatives

Abstract 3‐(2‐Di‐n‐propylaminoethyl)pyrrole (1a) was prepared in good yield by reduction of pyrrole‐3‐(N,N‐di‐n‐propylglyoxamide) (9) with lithium aluminum hydride. 3‐(2‐Di‐n‐propylaminoethyl)‐5‐acetylpyrrole (1b) was prepared by first acetylation of 1‐p‐toluenesulfonyl‐3‐(2‐di‐n‐propylaminoethyl)pyrrole (6) followed by hydrolysis of the p‐toluenesulfonyl substituent. The starting material 6 was prepared by homologation of 1‐(p‐toluenesulfonyl)pyrrole‐3‐carboxaldehyde (3) to the corresponding acetaldehyde followed by reductive amination of the latter.