Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTMolecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug DiscoveryMiniperspectiveJohn I. Manchester*†, Ed T. Buurman‡, Gregory S. Bisacchi†, and Robert E. McLaughlin‡View Author Information‡ †Department of Chemistry and ‡Department of Bioscience, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States*Phone: (781) 839-4844. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 6, 2532–2537Publication Date (Web):January 6, 2012Publication History Received23 September 2011Published online27 January 2012Published inissue 22 March 2012https://pubs.acs.org/doi/10.1021/jm201275dhttps://doi.org/10.1021/jm201275dreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views2251Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antibiotic resistance,Antimicrobial agents,Bacteria,Drug resistance,Membranes Get e-Alerts