Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Yanping Xu; Daniel Mayhugh; Ashraf Saeed; Xiaodong Wang; R. C. Thompson; Samuel J. Dominianni; Raymond F. Kauffman; Jaipal Singh; James S. Bean; William R. Bensch; Robert J. Barr; John J. Osborne; Chahrzad Montrose‐Rafizadeh; Richard W. Zink; Nathan Yumibe; Naijia Huang; Debra Luffer‐Atlas; Deepa Rungta; Dale E. Maise; Nathan B. Mantlo

doi:10.1021/jm034173l

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Xu et al. (2003) studied this question.

synapsesocial.com/papers/6a9287761bc865c26749fdf3 https://doi.org/10.1021/jm034173l

View Full Paper

Ask AI

Bookmark

Share

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Ask about this paper

Abstract

Discussion

Cite This Study

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading