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Ionic‐liquid‐anchored (2S,4R)‐4‐hydroxyproline 12 catalyzes direct asymmetric aldol reactions with comparable enantioselectivities in DMSO, and with superior enantioselectivities in neat acetone or 2‐butanone, than (S)‐proline (8) (up to 28 % ee difference) itself. Furthermore, the supported catalyst 12 can be easily recycled and reused for at least four times without significant loss of yields and enantioselectivity.
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Miao et al. (2006) studied this question.
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