Effects of parathyroid hormone on total protein, calcium, magnesium, phosphorus, sodium and potassium concentrations of normal human parotid saliva*

The effects of parathyroid hormone (PTH) administered to six young normal adult subjects on protein, calcium, magnesium, phosphorus, sodium and potassium concentrations in parotid saliva have been studied in relation to the salivary flow rate. Stensen's duct was cannulated and excretion patterns of the constituents determined before and after stimulation of saliva production by lemon juice. After a control period (period 1), 50 U of PTH were given i.v. followed by an infusion of 2 U/min for 60-90 min (period 2). In the absence of any detectable changes in plasma, PTH induced a significant rise of salivary protein, calcium, and phosphorus concentrations at rest and following lemon juice stimulation, and of sodium concentration, but only at high flow rates for the latter. PTH did not change magnesium and potassium excretions significantly. Control experiments without PTH were performed on five other subjects. Protein, phosphorus and potassium concentrations did not change significantly between period 1 and period 2. Calcium and sodium excretions were reduced and magnesium excretion increased during period 2. These results provide evidence that PTH acts on the parotid gland by affecting protein secretion and electrolyte transport. Possible mechanisms of these changes are discussed.