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At the flick of a switch: Introducing phosphate moieties into (Thr-Val)X peptide aggregation domains disturbs the formation of secondary structures. This suppression is used to regulate the self-assembly of polymer–peptide conjugates. A phosphatase enzyme which hydrolyzes the phosphate esters then triggers the self-assembly process generating fibrillar aggregates (see scheme).
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Kühnle et al. (2009) studied this question.
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