The identification of a suitable non-fluorescent molecule that can be oxidized by G-quadruplexes into a fluorescent product will be important for several fields such as bioanalyte sensing and cancer therapeutic discovery. Herein, we demonstrate that 2',7'-dichlorodihydrofluorescein diacetate is a superior reducing substrate for the fluorometric detection of bioanalytes using peroxidase-mimicking G-quadruplex DNAzymes.
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Nakayama et al. (2009) studied this question.
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