Addition of a rat CBG preparation to a progesterone solution abolished the effect of the hormone on the ligated uterus of the ovariectomized mouse. Inactivation was also observed when rat serum albumin was used as the progesterone-binding protein. These results seem to show that the biological activity of progesterone is suppressed by complex formation with CBG or with serum albumin. (Endocrinology85: 778, 1969)
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Hoffmann et al. (1969) studied this question.